| 초록 |
In the brain and central nervous system, dopamine plays a crucial role as a neurotransmitter for interneuronal communication. Therefore, dopamine detection is essential for medical diagnosis. Herein, we present a dopamine receptor expression system for the selective and sensitive detection of dopamine. We successfully achieved the overexpression of hDRD1 in a bacterial expression system, which has the advantage of convenience, low cost, and high productivity. The receptor integrated into the multidimensional carboxylated poly(3,4-ethylenedioxythiophene) nanofiber membrane based FET system. The FET device can be integrated into a poly(dimethyl siloxane)-based microfluidic system and retain its high performance in fluidics, which results in the generation of large-scale dopamine biosensors. |
