| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Mitochondria targeting doxorubicin delivery with bioreducible AB2 miktoarm polymeric carrier enhance therapeutic efficacy and survival rate in vivo |
| 초록 |
Recently intracellular targeting therapeutics delivery has attracted great attention in order to get enhanced therapeutic efficacy and reduced side effects. For mitochondria targeting doxorubicin (DOX) delivery, DOX was chemically conjugated with a bioreducible AB2 miktoarm polymer, which is composed of poly(ethylene glycol) (A) and poly(benzyl-l-aspartate) (B) blocks. Triphenylphosphorinum (TPP) as mitochondria targeting moiety was introduced physically or chemically to the self-assembled DOX-conjugated AB2 miktoarm nanoparticles (NPs). The size of the DOX and TPP loaded NPs were 100-200 nm in diameter. In vitro studies in KB and MDCK cells showed that TPP loaded NPs enhanced mitochondrial uptake ratio of DOX compared to free DOX. In vivo studies also demonstrated significant tumor size reduction with longer survival profile for TPP loaded NPs. |
| 저자 |
누런나비엠디1, 이영주1, 김유경1, Li Li1, 이용규2, 이은지1, 강한창3, 허강무1
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| 소속 |
1충남대, 2한국교통대, 3가톨릭대 |
| 키워드 |
miktoarm polymer; mitochondria targeting; triphenylphosphorinm; doxorubicin
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| E-Mail |
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