| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Synthesis of dual-responsive micelles based on Diels-Alder click reaction for effective doxorubicin delivery |
| 초록 |
A dual-responsive core cross-linked micelles based on amphiphilic block copolymer of poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(styrene-alt-maleic anhydride) (POEGMA-b-PSMA) was prepared. The POEGMA-b-PSMA triblock copolymers were synthesized by the RAFT polymerization and subsequently functionalized with furfuryl amine. Diels–Alder reaction was carried out to crosslink the hydrophobic core at 60 °C. The drug loading content and efficiency were estimated to be 18.0 (wt%) and 90%, respectively. TEM images showed spherical shapes of DOX loaded cross-linked micelles with an average hydrodynamic diameter of 70 nm. The micelles displayed a good stability under physiological condition but disassociated immediately under reductive acidic environment of tumors. Finally, the in vitro drug release showed that DOX release from micelles was only 11 % at pH 7.4, whereas 62% DOX was released at pH 5.0 and 10 mM glutathione. |
| 저자 |
임권택, Cuong M.Q. Le, Xuan Thang Cao
|
| 소속 |
부경대 |
| 키워드 |
Diels-Alder; Click Reaction; RAFT
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| E-Mail |
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