| 초록 |
Drug-eluting balloon (DEB) has been widely studied as a method of treating arterial disease instead of cardiovascular stents. However, DEB has some challenges in thrombosis and restenosis because of drug delivery efficiency. In this study, we tried to improve the drug delivery efficiency by multilayer coating on a balloon catheter. To minimize drug loss during the transit time and maximize drug transfer from DEB to the vessel wall, the multilayer coating on the balloon was composed of polymers that could be easily removed from the balloon and attached to the inner vessel wall. Drug nanoparticles were analyzed by DLS and TEM, and then the morphology and drug content on the DEB were observed by SEM and HPLC, respectively. Drug release profile and transfer from DEB were evaluated in vitro. These results suggest that the multilayer coating can be used as an advanced DEB platform for the treatment of cardiovascular diseases. |
