| 초록 |
Photo-immobilization techniques can be used to immobilize protein drugs in the body and to maintain the drug constantly. The drug immobilization material is a natural polymer that should have biocompatibility, biodegradability and low toxicity. In the food industry and drug delivery, gelatin has been selected as a harmless substance in this study, and photo-cured gelatin derivatives have the property of becoming hydrogel upon dissolution, making them suitable for application as protein drug immobilization and injections. 1H-NMR and FT-IR spectroscopy were demonstrated that azido group was introduced into Gelatin. In addition, cell proliferation experiments confirmed whether the immobilized protein drug had a lasting effect and was harmless in the body. The ability to immobilize drug was confirmed by fluorescent protein using fluorescence microscope. Based on these characteristics, Az-Gelatin is expected to be application in medical field. |
