| 초록 |
Previously, we have mathematically proved the drug diffusion trend of HPMC to improve eye dryness symptoms. Through the polymerization of ionic functional group and HEMA polymer, the diffusion tendency of the drug changed according to the change of tear pH, which confirmed the expansion / contraction of the contact lens and ionization reaction with external solution. In this study, we developed a silicone hydrogel contact lens and analyzed the effect of drug diffusion on polymerization ratio. We have demonstrated the mechanism of drug release mobility according to the ratio of silicon in the conditions of drug delivery. Changes in water content of the lens, porosity of the lens, and release characteristics of the drug showed differences in storage efficiency in the lens. Through these results, we believe that there is a possibility of development of drug contact lenses that can replace and improve the eye drops used in the treatment of various eye diseases including dry eye syndrome. |
