| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Study on Sustained and Controlled Release Behaviors for Application to Dual Drug-Eluting Stent |
| 초록 |
It is well known that the thrombus formation and the proliferation of the smooth muscle cells induced by injury after angioplasty of metal stents have generated in-stent restenosis inside them. To solve these problems the development of self-degradable scaffolds carrying drugs inhibiting the proliferation of the cells is urgently required. Biodegradable polymers containing alpha lipoic acid and ReoPro, a potent inhibitor that blocks the final pathway of platelet aggregation, were served as a drug carrier. The hierarchical structure composed of three layers of biodegradable polymers such as top, barrier, and bottom layers was formed by coated onto the stent surface by electrospray and ultrasonic nanocoating for constructing the successive release behavior of the dual drugs and mixed drugs. The kinetics of the release profiles and the cross section of the hierarchical structure were characterized with UV spectrometer and FE-SEM/AFM etc, respectively. |
| 저자 |
김동민1, 이봉수1, 강종희1, 박귀덕1, 손태일2, 한동근1
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| 소속 |
1한국과학기술(연), 2중앙대 |
| 키워드 |
stent; ALA; ReoPro; biodegradable polymer; electrospray
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| E-Mail |
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