| 학회 |
한국재료학회 |
| 학술대회 |
2020년 가을 (11/18 ~ 11/20, 휘닉스 제주 섭지코지) |
| 권호 |
26권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
In-vitro and in-vivo characterization of Ca-Sr-P/PLA-Hap coated Mg-Zn alloy for the orthopedic bone fixation. |
| 초록 |
Most materials of the bone fixation device are used by stainless and titanium alloy. But these materials occur stress shielding problems that need to removal operation by a year. Therefore Magnesium alloy based biodegradable bone fixation device is developed. But Mg-based material have a limitation that generates a critical amount of hydrogen gas, which can occur embolus. In this study, Ca-Sr-P/PLA-Hap coated Mg-Zn alloy based bone plate was developed for biodegrading rate control. Especially, the Microstructure and composition of Ca-Sr-P/PLA-Hap coated Mg-Zn alloy plate were evaluated by SEM, EDS, XRD, and FTIR. And, hydrogen gas generation rate and pH variance by biodegradation. Furthermore, cell viability and proliferation were evaluated by the MC3T3-E1 cell line. And In-vivo biocompatibility was performed by rabbit for a month. image and histological analysis were observed by micro-CT and H&E staining. |
| 저자 |
Seong-Su Park1, Byong-Taek Lee2
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| 소속 |
1Department of Regenerative Medicine, 2Soonchunhyang Univ. |
| 키워드 |
<P>PLLA; Mg alloy; biodegradable; bone plate</P>
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| E-Mail |
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