| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The effect of dynamic compression for cartilaginous tissue formation with bone marrow stromal cells |
| 초록 |
The mechanical stimulation is a very important factor for formation of articular cartilage. The objective of this study is to evaluate the effect of dynamic compression for differentiation of bone marrow stromal cells (BMSCs) within an elastic scaffold and cartilaginous tissue formation. Highly elastic scaffolds were fabricated from poly (L-lactide-co-carprolactone)(5:5) by a gel-pressing method. BMSCs were seeded onto the scaffolds and the continuous compressive deformation was applied to them with 0.1Hz and 5% strain for 10 days in the chondrogenic media. Also, the chondrocytes-seeded constructs were implanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation. From the results, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chongenic lineage and to maintain their phenotypes. Consequently, it may improve the quality of cartilaginous tissue formed in vitro and in vivo. |
| 저자 |
정영미1, 김수현1, 김상헌1, 김영하2, Jun Xie3, Takehisa Matsuda4, 민병구3
|
| 소속 |
1한국과학기술(연), 2광주과학기술원, 3Kyushu Univ., 4Department of biomedical engineering |
| 키워드 |
compression; mechanical stimulation; bone marrow stromal cells; cartilage tissue engineering
|
| E-Mail |
|
