| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Temperature-triggered Self-assembly of Elastin-resilin Fusion Proteins for Advanced Drug Delivery |
| 초록 |
Stimuli-responsive polypeptide-based block copolymers that can be self-assembled into various nanostructures have been studied for drug delivery applications. We report herein molecular design, expression, purification and characterization of elastin-resilin fusion proteins and their temperature-triggered self-assembly. Temperature-responsive fusion proteins composed of elastin-based polypeptides (EBPs) and resilin-like polypeptides (RLPs) were genetically engineered, purified by inverse transition cycling, and the thermally induced self-assembled nanostructures were characterized by thermal profiling, dynamic light scattering and transmission electron microscopy. These self-assembled nanostructures were reversibly formed in response to the change in temperature depending on the temperature-responsiveness of EBP and RLP fusion proteins. The EBP and RLP fusion proteins with tunable thermo-responsive properties would make them attractive for advanced drug delivery systems. |
| 저자 |
Aamna Basheer1, 이재상2, 강민정3, 임동우1
|
| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus |
| 키워드 |
Elastin; Resilin; Self-assembly; Temperature responsiveness; Drug delivery
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| E-Mail |
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