| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Surface Adhesive Block Copolypeptide Hydrogels with Stimuli-responsiveness |
| 초록 |
Surface adhesive proteins bioinspired from mussel foot proteins (MFPs) have been of growing interest for biomedical applications. Especially, 3, 4-dihydroxyphenylalanine (DOPA) residues of MFPs are used for surface adhesion via covalent cross-linking. In this study, we present ABA type tri-block copolypeptides composed of MFP and elastin-based polypeptide (EBP) with thermal responsiveness to develop injectable polypeptide hydrogels with surface adhesive properties. Hydrogelation of EBP-MFP-EBP triblock copolypeptides occurred for several minutes under physiological conditions by oxidation of DOPA into dopaquinone with sodium periodate and thermally triggered EBP aggregation. Furthermore, these block copolypeptide hydrogels showed controlled bulk adhesive properties in moisture condition. In conclusion, the surface adhesive hydrogels with stimuli-responsiveness would be potential as tissue adhesives for tissue engineering and regenerative medicine. |
| 저자 |
이재희1, 이재상2, Aamna Basheer1, 강민정2, 임동우1
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ. |
| 키워드 |
Elastin-based polypeptides; Mussel foot proteins; Sodium periodate; Surface adhesive; stimuli-responsiveness; Hydrogel
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| E-Mail |
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