| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Surface Enhanced Raman Scattering-based Bioimaging of Biohybrid Nanoprobes with Silver Nanoclusters |
| 초록 |
Surface Enhanced Raman scattering (SERS)-based bioimaging has been of great interest due to high sensitivity, good photostability and excellent capability for multiplex detection of biomarkers. In this study, a new class of biohybrid SERS nanoprobes with silver nanoclusters (Ag NCs) was developed for highly sensitive cancer cell imaging. Raman dye-induced Ag NCs were embedded within submicron sized polymer particles with variable densities via electrohydrodynamic jetting, followed by chemical stabilization. The polymeric particles with Ag NCs provide a variety of functional groups for conjugation of biomolecules. The HER2 antibody-modified biohybrid nanoprobes were selectively bound to the SKBR3 human cancer cells expressing HER2 biomarkers when incubated with the cells, and showed strong SERS-based imaging signals of the cancer cells with high sensitivity. Various Raman reporters and biomolecules could be introduced to the biohybrid nanoprobes for multiplexed targeting and imaging. |
| 저자 |
굴람자라니1, 이상엽2, 정찬우1, 주재범2, 임동우1
|
| 소속 |
1한양대, 2생명나노공학과 |
| 키워드 |
Surface enhanced Raman scattering; Silver nanoclusters; Electrohydrodynamic jetting; Bioimaging
|
| E-Mail |
|
