| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fibroblast-derived extracellular matrix-covered Co-Cr stents for endothelial progenitor cell delivery |
| 초록 |
Rapid re-endothelialization at the inserted stent in atherosclerotic lesion may be effective to reduce or to prevent local restenosis and thrombosis. In this study, fibroblast-derived extracellular matrix (FDM) was fabricated on cobalt-chromium alloy (Co-Cr), resulting in a reservoir, for delivery of endothelial progenitor cell (EPC). Since EPC can be differentiated to endothelial cell (EC) in a suitable condition, like extracellular matrix (ECM), we established covalent bond formation between Co-Cr and FDM using carboxyl ended-self assembly monolayer (SAM) on Co-Cr surface. We assumed that covalently bounded FDM on Co-Cr is effective for EPC delivery even in the blood flow. Fibroblast cultured was decellularized by treating Triton X-100 and NH4OH, and the FDM structure was defined by immunostaining. In summary, we expect that FDM-bound Co-Cr surface may accelerate re-endothelialization as compare to bare metal surface. |
| 저자 |
민일재1, 김병수2, 김익환3, 정윤기1, 한동근1
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| 소속 |
1한국과학기술(연), 2서울대, 3고려대 |
| 키워드 |
stent; extracellular matrix; endothelial progenitor cell; re-endothelialization; surface modification
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| E-Mail |
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