| 초록 |
Polymer micelles have many benefits for tumor chemotherapy, such as the resistance to rapid renal clearance, unwanted uptake by the reticuloendothelial system, and passive targeting by the enhanced permeability and retention effect. However, the assembled structure of polymer micelles tends to dissociate upon intravenous administration due to their low structural stability. Therefore, they can neither hold entrapped drugs in the extracellular fluid nor specifically release drugs in the intracellular fluid of target cells. Herein, we report on acid-labile ketal cross-linked polymer micelles for effective intracellualr delivery of doxorubicin (DOX). Ketal cross-links could act as effective tools to maintain micellar stability in extracellular conditions, and could be cleaved to facilitate the release of DOX in endosomal pH. In vitro experiments supported the endosomal/lysosomal uptake of ketal-cross-linked micelles and the subsequent DOX release into cellular nuclei. |
