| 초록 |
Ethosomes are composed of phospholipids, water and ethanol. Ethanol allows them to penetrate more easily into the deeper layers of the skin by fluidizing the lipid domain of the stratum corneum. In addition, the flexibility of ethosome was enhanced by adding edge activator. In this study, we performed effects of edge activators on the formation into ethosome. Sodium cholate, sodium deoxycholate, and Tween 80 were tested as edge activators. The change of particle size, membrane permeability and dermal absorption of ethosome with constituent composition was examined. The properties of sample were analyzed by the means of PCS, TEM and FAIM. |
