| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Improvement of Dissolution Rate of Prothionamide and PVP K-30/Eudragit RSPO Solid Dispersion by Spray Drying |
| 초록 |
The purpose of this study, prothionamide synthesized with two polymers can improve release characterization with spray drying. The solid dispersion was formulated by added hydrophilic PVP K-30 for enhanced biocompatibility, and increased eudragit® RSPO. SEM was used to observe surface of solid dispersion from confirm a sphere of solid dispersion, DSC and XRD were used to analyze the amorphous of solid dispersion. The in vitro test was carried out to find improved dissolution rate of valsartan solid dispersion in intestinal juice and controlled experiment was carried out to compare valsartan solid dispersion with original drug. These results suggested that we confirmed that the change of amorphous crystallization, the release characterization and the increase in dissolution rate follow the polymer ratio when the formulation prepared by spray drying. |
| 저자 |
조원형, 송병주, 오명준, 조한수, 서한솔, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Prothionamide; PVP K-30; Eudragit RSPO; solid dispersion.
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| E-Mail |
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