| 초록 |
Understanding the physiology of the vascular system has been an important research topic, particularly for the diagnosis and treatment of various vascular diseases. Recent studies based on the microfluidic system have created in vitro models that recapitulate both fluidic and (bio) chemical features of the in vivo vasculature which allows for the physiological study of the vasculature with a great simplicity. Here, we develop a soft tubular microfluidic device (STuFl) which, besides the fluidic and (bio)chemical features, mimics both geometrical and mechanical properties of blood vessels, i.e. a tissue-like soft tube with a circular cross-sectional area. STuFl also allows generating micro-patterns at tube’s inner walls, mimicking a pathological state of vascular diseases, e.g. arteriosclerosis. We present the method to develop STuFl through a photo-polymerization of PEGDA, which is controlled by a synchronized manipulation of the photo-initiator concentration and the UV exposure dose. |
