| 초록 |
Extracellular vesicles (EVs) are nano-sized particles derived from living organisms. Although EVs produce from cell culture are utilized in various diseases, however, large quantities of EVs are needed for in vivo applications, which requires high production cost and time. Accordingly, plant-derived EVs are an emerging alternative for culture-derived EVs. In this study, the isolated cabbage-derived EVs (Cabex) and red cabbage-derived EVs (Rabex) were supplemented to culture media, and there was no cytotoxicity effect in human cells. In addition, both Cabex and Rabex promoted cell proliferation and, suppressed inflammation in immune cells and apoptosis in human cells. Finally, therapeutic drugs were encapsulated in Cabex or Rabex and successfully delivered to human cells, demonstrating the potential of these EVs as alternative drug delivery vehicles. Overall, the current results provide strong evidence for the wide application of Cabex and Rabex as novel therapeutic biomaterials. |
