| 초록 |
As one of the anticonvulsant drugs, phenytoin is most commonly used in the epilepsy treatment with a therapeutic concentration range of 10−20 μg/mL. The continuous medication monitoring is required for the minimization of toxicity risk and high efficacy. Various sensing systems based on molecular imprinted polymers (MIPs) as recognition element have been established to determine the quantity of phenytoin. In general, the MIP-based sensor systems provide numerous advantages such as simple preparation, high reliability, chemical and thermal stability. Thus, in this study, we introduce a novel strategy for selective phenytoin detection on the surface of MIP films using an extended-gate field-effect transistor (EG-FET) as a signal transducer to monitor the minute changes in potential on the gate surface in the presence of charged analytes. |
