| 초록 |
Thermogelling Pluronic F127 has been studied extensively as a biocompatible material for drug delivery system and tissue engineering. In this study, novel temperature-sensitive, biocompatible F127 derivatives were synthesized, and cell-adhesion peptide, Arg-Gly-Asp (RGD), was then grafted to F127-glycolide-4-methacryloxyethyl trimellitic anhydride (FGM). These functional polymers were characterized by 1H-NMR, FTIR, GPC, and elemental analysis. Not only CMC of FGM-RGD, but also sol-to-gel transition temperature of 20% of FGM-RGD were lower than those of F. DLS suggests that near critical micelle temperature, FGM-RGD formed large particles in water and the content of large particles decreased noticeably as the temperature increased more than 35 oC. These phenomena were confirmed by TEM. DLS and 13C-NMR support that balanced interactions in polymer network between hydrophobicity and charges may be responsible for the dynamical behaviors of the large particles in FGM-RGD aqueous solutions. |
