| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-에너지저장.변환 |
| 제목 |
Dual stimuli-sensitive zwitterionic fluorescence nanoparticle for cancer cell imaging |
| 초록 |
A novel zwitterionic fluorescent nanoparticle (ZFNPs) containing polysulfobetaine groups with BODIPY fluorophores and graphene oxide (GO) plates are prepared for the detection of tumor cells in response to the intra and extracellular stimuli. The fluorescence intensities of the ZFNPs are highly influenced by temperature and pH. Because of the extraordinarily high quenching efficiency of GO, the ZFNPs exhibit minimal fluorescence intensity at physiological temperature and pH, while strong emissions are observed at endosomal/lysosomal and basic pH condition. AFM measurement reveals different thicknesses of the ZFNPs against pH changes from acidic to basic. Confocal images of the prepared ZFNPs against MDA-MB 231 breast cancer cells confirm the intense green fluorescence at low and high pH values but no fluorescence signal under physiological pH condition enabling the ZFNPs as a novel fluorescence probe. |
| 저자 |
김성한, Tamim Mosaiab, 박성영
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| 소속 |
한국교통대 |
| 키워드 |
BODIPY; catechol; Cell imaging; fluorescent nanoparticles; graphene Oxide
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| E-Mail |
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