| 초록 |
Natural killer (NK) cells are a specialized immune effector cell that is attracting attention as a T cell substitute, playing an important role in activating immune against cancer. Here, we designed multifunctional NK cell coating materials to enhance anticancer effect. This platform has 6 major functional moieties; (1) cell surface anchoring lipid, (2) intracellular penetration blocker, (3) positive charge moiety, (4) fluorescence dye, (5) cancer recognition moiety, and (6) stimuli responsive degradable linker. NK cell was homogeneously coated and remained for 48 hr. Intrinsic properties of coated NK cells were not inhibited. Moreover, cancer recognition and anticancer ability of NK cells were enhanced. Anti-folate was released from the dissociated coating material in response to leaked glutathione from disrupted cancer cells, inducing secondary anticancer efficacy. Therefore, this multifunctional NK cell coating approach could be utilized as an efficient cancer immunotherapy. |
