| 초록 |
Hydrophilic photosensitizers (HP) are appropriate wavelength light susceptible molecules that are essential for photodynamic therapy (PDT). The photosensitizers absorb photon energy at an appropriate wavelength and generate singlet oxygen and reactive oxygen species (ROS). However, the HP does not have cancer selective targeting ability, which it accumulated in extensively various tissues accompany with side effect of phototoxicity. To solve this limitation, we selected folate, which has been established to be an effective cancer targeting moiety. Herein, we created two types of cancer-selectable HPs conjugated with folate (HP2KF and HP4KF). HP4KF showed a folate receptor-mediated cancer-selective cellular uptake and induces cancer death. The folate receptor mediated cancer-selective internalization of HP4KF was confirmed by competitive interaction with folate in MDA-MB-231 human breast cancer. We believe that HP4KF will be suitable material in cancer targeted therapy. |
