| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 | 22권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Enhanced Injectable Cell Laden Heparin-Poloxamer/Gellan Gum Hydrogels |
| 초록 | Gellan Gum(GG) has the advantage of being injectable but gelation temperature of the GG is too high (about 42 ℃) which cells suffer from harsh condition. Herein, heparin-poloxamer (HP) which is a thermo-sensitive polymer was used to lower GG gelation temperature and provide better microenvironment for cells. FTIR, SEM, compressive strength, rheological characterization, swelling ratio and degradation was evaluated to characterize the hydrogels. Also live/dead and cell viability was measured to identify enhanced hydrogel microenvironment. The result showed enhanced tunable mechanical properties of hydrogels, and lower gelation temperature of GG (about 37 ℃) provided appropriate environment for cell encapsulation. Also higher stem cell marker was expressed in HP/GG hydrogels. This research was supported by a grant of the Korea Health Technology R&D Project through KHIDI, funded by the Ministry of Health &Welfare, Republic of Korea (HI15C2996 ). |
| 저자 | 최옥균, 강길선 |
| 소속 | 전북대 |
| 키워드 | hydrogel; gellan gum; heparin; poloxamer; bmsc |
