| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Antibody Mediated Oral Delivery of Therapeutic DNA for Type 2 Diabetes Mellitus |
| 초록 |
Oral delivery of DNA has emerged as a novel therapeutic for diverse applications. We designed a recombinant human IgG Fc fragment to attain neonatal FcRn receptor (FcRn) mediated active uptake and transport of plasmid DNA (pDNA). The designed recombinant antibody had nine arginine groups on C- terminus of human IgG1 Fc fragment (hIgG-Fc-9Arg) to facilitate electrostatic interactions with pDNA. We showed an efficient ratio of hIgG1-Fc-9Arg/pDNA to cellular uptake and release therapeutic proteins such as Glucagon-like peptide 1(GLP-1) in FcRn receptor expressed cells in vitro. An in vivo type 2 diabetes treatment study by oral administration of hIgG1-Fc-9Arg/pDNA complexes showed absorption in GI track to balb/c male mice. The oral delivery of hIgG1-Fc-9Arg/pDNA complexes to target cell delivery appears a promising approach to achieve potent treatment of type 2 diabetes. |
| 저자 |
이선화1, 강성훈1, 이용규2
|
| 소속 |
1kb바이오메드, 2한국교통대 |
| 키워드 |
Antibody; Oral delivery; Type 2 Diabetes Mellitus
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| E-Mail |
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