| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
TUMOR-TARGETED DELIVERY OF POLYMERIZED VEGF siRNA USING THIOLATED GLYCOL CHITOSAN NANOPARTICLES FOR TREATMENT OF AVASTIN RESISTANT HEAD AND NECK CANCER |
| 초록 |
Various anticancer agents have been used in cancer therapy due to therapeutic effect based on its own mechanism of action. But, tumor resistance to current anticancer agents is a main defect in cancer therapy. Avastin is a therapeutic antibody neutralizing VEGF to suppress the tumor growth. But, it also has side effects such as high blood pressure and bleeding limiting its therapeutic application. In this study, small interfering RNA(siRNA) suppressing VEGF expression was delivered to Avastin resistant tumors to overcome the drug resistance of cancer. |
| 저자 |
정지훈, 김명구
|
| 소속 |
성균관대 |
| 키워드 |
poly siRNA; VEGF; Avastin
|
| E-Mail |
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