| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Cellular Uptake Mechanism of Hydrophobically Modified Glycol Chitosan Nanoparticles. |
| 초록 |
Hydrophobically modified glycol chitosan (HGC) nanoparticles are used to drug delivery system, molecular imaging, and so on. To investigate uptake mechanism of HGC nanoparticles, we experiment on H2B-GFP stable HeLa cell line with HGC nanoparticles. We confirmed the characteristics of HGC nanoparticles, and studied its intracellular uptake pattern according to dose and time series. The cellular uptake mechanism of HGC nanoparticles were studied using by cellular uptake inhibitors as a chloropromazine, filipin III, and amilorid. Finally, We observed the cellular images using by confocal laser scanning microscopy. |
| 저자 |
정현진1, 남혜윤1, 오유경2, 김광명1, 권익찬1
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
HGC; cellular uptake; inhibitor; confocal laser scanning microscopy
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| E-Mail |
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