| 초록 |
Recently, photothermal therapy (PTT) is advancing especially their targeting properties due to inefficient cancer killing which leave opportunity to improve their effectivity. By this fact, a polyethylene glycol based polymer (PgP) conjugated to hyaluronic acid-reduced graphene oxide (HA-rGO) followed by IR825 loading was synthesized for responsive bioimaging and targeted photothermal therapy for cancer cells killing using near-infrared dye (NIR). The fluorescent emission of nanoparticle was observed after pH treatment compare to physiological condition (pH 7.4) and demonstrated cell killing capabilities when irradiated with NIR due to cytotoxicity of PgP/HA-rGO. Overall, the developed PgP/HA-rGO nanomaterials can be applied as a smart drug delivery system with combination of bioimaging and cell killing which has good selectivity and compatibility, demonstrating great potential for biomedical applications. This work was supported by Korea National University of Transportation in 2018. |
