| 초록 |
The phase transformation of guanosine 5-monophosphate (GMP) in Couette-Taylor (CT) crystallizer was mathematically modeled and experimentally monitored at the steady state. For the modeling, the phase transformation was assumed to occur via consecutive steps of the dissolution of amorphousGMP and growth of the crystalline GMP hydrate in the solution and CT crystallizer was simply behaved as like plug flow one.Themass fractions in GMP solid (amorphous, crystallinehydrate) and solution phases were monitored by FT-IR and UV/Visspectroscopy, along with axial direction ofCT crystallizer. Therotation speedof inner cylinder and feed concentration were varied to examine their impact on the phase transformation. According to the comparison of the experimental results with model predictions,both steps of dissolution and growth of GMP solids contributed competitively to the phase transformation. Also, the phase transformation was significantly promoted as increasing the rotation speed and decreasing the feed concentration. Thesimple mathematical modelwas quite successful to describe the experimental results. |
