| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Robust Drug Carrier Based on Hyaluronic Acid Nanoparticles with High Biostability and Tumor Targetability |
| 초록 |
Self-assembled polymeric nanoparticles have emerged as promising vehicle for the delivery of imaging and therapeutic agents. As these polymeric nanoparticles are in the physically self-assembled state, they suffer from poor in vivo stability in the diluted condition after intravenous injection. Therefore, considerable amount of drugs may be released before reaching their target site, causing severe toxicity. In the present study, an attempt has been made to improve the stability of the hyaluronic acid (HA)-based nanoparticles through a facile crosslinking method. The physicochemical characteristics and stability of the HA nanoparticles were investigated in detail using various analytical techniques. |
| 저자 |
한화승, Gurusamy Saravanakumar, 허로운, 박재형
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| 소속 |
성균관대 |
| 키워드 |
crosslinked nanoparticle; hyaluronic acid; biostable nanoparticle; micelle; disulfide
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| E-Mail |
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