| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Functional Peptide Containing Injectable Hydrogels for Deliverying Bioactive Agents |
| 초록 |
To deliver therapeutic agents, injectable hydrogels have attracted a lot of interests because of high water contents and the ability to deliver them in a minimally invasive manner. Herein, we designed injectable hydrogel materials using functional peptides including gelatin, albumin and lysozyme. Gelatin peptide contains abundant Arg-Gly-Asp (RGD) sequences which can serve as cell attachment sites recognized by many integrins, so cell adhesion and viability can be facilitated after transplantation. Also, albumin and lysozyme are expected to interact with various bioactive molecules, so enhanced sustained release behavior can be expected when it is employed in delivery carriers. Bioactive agents including proteins and cells were incorporated into the functional peptides based hydrogels and transplanted subcutaneously, and we investigated the controlled release behaviors of hydrogels and resultant therapeutic effects. |
| 저자 |
이승용1, Muhammad R. Haque1, 정지헌2, 변영로1, 안철희1
|
| 소속 |
1서울대, 2영남대 |
| 키워드 |
injectable hydrogel; protein delivery; cell delivery
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| E-Mail |
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