| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Blend System Hydrogels with Enhanced Mechanical Properties for Islet Cell Delivery Carrier |
| 초록 |
Hydrogels are of great interest as potential candidates for cell delivery carrier. In this study, we designed a novel blend system hydrogel with high mechanical properties for islet cell delivery. Firstly, Pluronic F127 was simply modified into two types of functional groups, thiol and pyridyl disulfide, respectively. In physiological environment, gelation occurs firstly via micelle packing mechanism of Pluronic F127 and thiol-disulfide exchange reaction which can be thought as a driving force of mechanically stable hydrogel system happens at the shell of micelles. The properties of resultant chemically as well as physically crosslinked Pluronic hydrogels showed highly increased mechanical properties in physiological environment by sol-gel phase diagram, in vitro and in vivo experiment. Further, by in vivo experiment, it is expected that this hydrogel system can be applied to islet cell delivery system for controlling high glucose level in blood. |
| 저자 |
이승용, 정지헌, Muhammad Rezwanul Haque, 변영로, 안철희
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| 소속 |
서울대 |
| 키워드 |
hydrogel; cell delivery; islet cell
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| E-Mail |
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