| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 |
27권 1호, p.38 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
GALACTOSYLATED CHITOSAN-graft-POLY(VINYL PYRROLIDONE) AS HEPATOCYTE-TARGETING DNA CARRIER |
| 초록 |
Chitosan has been widely used in pharmaceutical research and in industry as a carrier for drug delivery and as biomedical materials for artificial skin and wound healing bandage applications due to its non-immunogenecity, good biocompatibility and non-toxicity. In previous studies, galactosylated chitosan (GC)-graft-dextran and GC-graft-poly(ethylene glycol) (PEG) were synthesized and checked as hepatocyte-targeting gene carriers. The complexes were stable and non-toxic. Also, the transfection of the complexes only occurred in the cells with asialoglycoprotein receptors (ASGPR), as a indication of receptor-mediated delivery of DNA into the hepatocyte. But transfection efficiency of the complexes was still low compared with that of lipofection. In this study, the GC-graft-PVP (GCPVP) was prepared and characterized. Also, the complex formation between GCPVP and DNA was checked for hepatocyte-targeting gene carrier. |
| 저자 |
박인규1, 임종은2, 박영환*3, 최윤재4, 김수일5, 김원종**, T. Akaike**, 조종수
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| 소속 |
1서울대, 2*서울대, 3**Dept. of Biomeolecular Engineering, 4Tokyo Institute of Technology, 5Japan |
| 키워드 |
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| E-Mail |
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| VOD |
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