| 초록 |
Less toxic zinc oxide (ZnO) quantum dots (QDs) were synthesized by utilizing the cavity of the apoferritin from horse spleen in order to utilize these nanoparticles as a neurotransmitter sensor. The characterization study showed that the QDs were monodispersed and the size of QDs was about 4 nm. In addition, the photoluminescence (PL) spectrum change was investigated by accompanying its conjugation with a neurotransmitter dopamine. When the ZnO QDs-apoferritin was conjugated with dopamine, a significant quenching of the fluorescence occurred and the PL intensity was a linear function of the dopamine concentration. For investigating the selectivity of ZnO QDs-apoferritins over other neurotransmitters, they were conjugated with other neurotransmitters such as gamma amino butyric acid (GABA), histamine (HA), uric acid (UA) and L-ascorbic acid (AA). Indeed, it was found that the ZnO QDs-apoferritin nanodots can be employed as a useful sensing media for tiny concentration of dopamine. |
