| 학회 |
한국재료학회 |
| 학술대회 |
2010년 가을 (11/11 ~ 11/12, 무주리조트) |
| 권호 |
16권 2호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Insitu conjugated GRGD- oxidized alginate/gelatin/BCP hydrogel |
| 초록 |
Hydrogels have many applications in regeneration medicine such as scaffold for tissue engineering. The hydrogel scaffolds have been exhibited biocompatibility, its degradation products with nontoxicity for promoting cell attachment and tissue formation. The oxidation reaction sodium alginate cleaves the carbon-carbon bone of the cis- diol group and leads to the formation of active aldehyde group. This treatment is also helpful to couple peptides to alginate backbone, incorporation was achieved by functionalizing the amine terminus of the peptide to aldehyde group, thereby enabling the adhesion peptide to hydrogel. The obtained product is not only helpful area crosslinking groups in preparation of hydrogels but also is utilized to conjugate bioactive molecules to polysaccharide backbone. Herein, oxidized alginate was insitu conjugated with GRGD for promoted osteoblast adhesion and spreading on hydrogel composite oxidized alginate/ gelatin/ BCP. 1H NMR and XPS confirmed the GRGD grafted to oxidized alginate. Moreover, the viability of MG 63 osteoblast cell growing on hydrogel analyzed by MTT, was also well correlated with the GRGD content modified oxidized alginate. These hydrogels could be promising biomaterial for bone regeneration. |
| 저자 |
Nguyen Thi Phuong, Young Ki Min, Hun Mo Yang, Ho Yeon Song, Byong-Taek Lee
|
| 소속 |
Department of Biomedical Engineering and Materials |
| 키워드 |
: oxidized alginate; hydrogel; gelatin; biphase calcium phosphate; GRGD
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| E-Mail |
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