| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I(영어발표) |
| 제목 |
Enhanced cancer immunotherapy by in situ nanomicelle-generating dissolving microneedles |
| 초록 |
Efficient delivery of tumor antigens and immunostimulatory adjuvants into lymph nodes is crucial for the maturation and activation of antigen-presenting cells (APCs), which subsequently induce adaptive antitumor immunity. Dissolving microneedle (MN) has been considered as an attractive method for transcutaneous immunization due to its superior ability to deliver vaccines through the stratum corneum in a minimally invasive manner. However, since dissolving MNs are mostly prepared using water-soluble sugars or polymers for their rapid dissolution in intradermal fluid after administration, they are often difficult to formulate with poorly water-soluble vaccine components. Here, we develop amphiphilic tri-block copolymer-based dissolving MNs in situ that generate nanomicelles (NMCs) upon their dissolution after cutaneous application, which facilitate the efficient encapsulation of poorly water-soluble toll-like receptor 7/8 agonist (R848) and the delivery of hydrophilic antigens. The sizes of NMCs range from 30 to 40 nm, which is suitable for the efficient delivery of R848 and antigens to lymph nodes and promotion of cellular uptake by APCs, minimizing systemic exposure of the R848. Application of MNs containing tumor model antigen (OVA) and R848 to the skin of EG7-OVA tumor-bearing mice induced a significant level of antigen-specific humoral and cellular immunity, resulting in remarkable anti-tumor activity. |
| 저자 |
Nak Won Kim1, Sun-Young Kim1, Jung Eun Lee1, Yue Yin1, Jong Han Lee1, Su Yeon Lim1, E Seul Kim1, Hong Kee Kim2, Sohyun Kim3, Jung-Eun Kim1, Min Sang Lee1, Yong Taik Lim1, Ji Hoon Jeong1
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| 소속 |
1Sungkyunkwan Univ., 2Raphas Co., 3Ltd. |
| 키워드 |
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| E-Mail |
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