| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Guiding Tissue Regeneration of Rabbit Bone Defects using Silk Fibroin-Poly(glycolic acid) Hybrid Scaffolds Fabricated by Electrospinning and 3D Printing Techniques |
| 초록 |
Tissue engineering aims regeneration of defected biological tissues and organs by combining cells, scaffolds, and growth factors. We prepared patient-customizable guided bone regeneration (GBR)/guided tissue regeneration (GTR) hybrid scaffolds by electrospinning and 3D printing techniques. Poly(glycolic acid) (PGA) scaffolds were fabricated using a 3D printer. The microstructure of silk fibroin and PGA hybrid scaffolds was observed by SEM. Cell proliferation of osteoblasts on a PGA scaffold was analyzed. Rabbit bone defect model was used for animal test. Regenerated tissues were analyzed by H&E staining and micro-CT. Silk fibroin nanofiber-PGA scaffold groups showed significant regeneration of bone compared to control groups. The silk fibroin nanofiber-PGA scaffold construct will provide a prospective approach for regeneration of bone defects. |
| 저자 |
곽동민, 고영광, 권오형
|
| 소속 |
금오공과대 |
| 키워드 |
Guiding Tissue Regeneration; Hybrid scaffolds; Electrospinning; 3D printing
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| E-Mail |
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