| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Redox-sensitive Bioimaging Probe and Controllable Paclitaxel Drug Carrier Based on Disulfide-crosslinked Hyaluronic Acid |
| 초록 |
A redox-sensitive controllable release of hydrophobic drug was synthesized from carbonization of disulfide cross-linked hyaluronic acid followed by attachment of MnO2 nanosheets as responsive fluorescent “off/on” bioimaging probe. The encapsulation of fluorescence nanoparticle (FNP) by MnO2 reduces the system fluorescence intensity due to Förster resonance energy transfer (FRET) allowing quenching to the system (fluorescent “off”). In the presence of glutathione (GSH), MnO2 undergo reduction process to form Mn2+ while cleaves the disulfide bond resulting in the release of paclitaxel (PTX) from PTX-MnO2/FNP and increase the fluorescence intensity (fluorescent “on”). Overall, the synthesized PTX-MnO2/FNP structure can serve as a smart drug carrier with the combination of diagnostic and therapeutic properties promising great potential for medical applications. This work was supported by Korea National University of Transportation in 2018. |
| 저자 |
Benny Ryplida, Sung Young Park
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| 소속 |
한국교통대 |
| 키워드 |
Redox-responsive; MnO2 nanosheets; Fluorescence Carbon Nanoparticle; Drug Delivery System; Theragnosis
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| E-Mail |
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