| 초록 |
Although various transcatheter embolic agents have been developed, they still have challenges such as injectability and migration. To overcome these, shear-thinning hydrogels via host-guest interaction between β-cyclodextrin (β-CD) and adamantane (Ada) have been studied, allowing injection through a syringe or catheter due to viscous flow under shear stress. Herein, we developed an injectable hydrogel composed of Tetronic-Ada (Tet-Ada) and poly(β-CD) for effective embolization and release of a hydrophobic drug, Doxorubicin (DOX). The viscosity of the hydrogel, according to the shear rate, can be controlled by varying the polymer concentrations (7.5-12.5 wt%). The cyclic deformation test showed shear-thinning and rapid recovery properties. Moreover, the sustained release of DOX (~57% in 30 days) was investigated in vitro. In conclusion, we expect Tet-Ada/poly(β-CD) hydrogel can be a promising embolic material. Acknowledgement: [MOTIE/KEIT] 10062079 & 2018M3A9B5021319 |
