| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Tannin-based nanoformulation for hydrophobic drug delivery |
| 초록 | Tannins are polyphenolic compounds ubiquitously found in plants that possess antioxidant and anticancer activity. Among them, a representative hydrolysable tannin, Tannic acid (TA), has attracted attention as a nanocarrier for therapeutics due to their amphiphilic nature; it shows strong affinity to biomacromolecules via multivalent hydrogen bonding and hydrophobic therapeutics via π–π stacking. Herein, we synthesized a nanoformulation of a hydrophobic anticancer drug, paclitaxel (PTX), and a hydrophilic biopolymer poly(ethylene glycol) (PEG) via TA as a molecular glue. The synthesized nanoparticles showed superior colloidal stability in aqueous medium up to 7 days with a size of ~150 nm. *This work was carried out with the support of “Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01323201)” Rural Development Administration, Republic of Korea |
| 저자 | 김지연, 홍선기 |
| 소속 | 대구경북과학기술원 |
| 키워드 | tannic acid; paclitaxel; nano-formulation; drug delivery system |
