| 초록 |
In a living organism, cells are exposed to a number of external stimuli by the surrounding environment and these stimuli regulate cells to maintain specific functions. Among various changes in the external environment, we were interested in the physical pressure on the cells. Macrophages can be polarized into M1 and M2, which play different roles depending on the environment. In this study, we developed a culture system that can simulate specific stimulation with hydrogel for the macrophages in vivo. It is designed to simultaneously deliver a hypoxic environment and physical pressure, resulting in the cells' polarization. And then we confirmed the polarization of the macrophage from monocyte to M1, M2, and Giant cell through biological analysis. Through this study, it is expected that the regulation of the polarization of immune cells through the change of the surrounding environment will provide a new perspective in understanding the immune response from various environments. |
