| 초록 |
Biological cells are complex living machines that have garnered significant attention for their potential to serve as a new generation of regenerative medicine and bioreactors. Because of their secretion and differentiation, therapeutic cells such as fat-derived mesenchymal stem cells have tremendous potential to treat or even cure various diseases and injuries that have defied conventional therapeutic strategies. Therapeutic cells can be systemically or locally transplanted. Despite some impressive results with in vitro studies, there remain several obstacles to their broader development, such as a limited ability to control their transport and engraftment in vivo. We have been working to resolve these challenges by engineering cell surface with polymeric nanoparticles and microparticles that, in turn, improve the therapeutic efficacy of cells. This talk will focus on introducing synthesis of hyperbranched bioactive polymers and assembly of polymeric nanoparticles, each of which regulates transports and antioxidative activites of stem cells, respectively. The talk will also include future considerations that should be taken into account to advance the quality of cell surface engineering. |
