| 학회 | 한국화학공학회 |
| 학술대회 | 2013년 가을 (10/23 ~ 10/25, 대구 EXCO) |
| 권호 | 19권 2호, p.1475 |
| 발표분야 | 분리기술 |
| 제목 | Pure indomethacin-saccharin cocrystal powders by a combination of antisovlent and cooling methods |
| 초록 | Indomethacin (IMC) is a nonsteroidal anti-inflammatory drug (NSAID) classified as BCS II. Recently reported anti-solvent method was saccharin used in obtaining indomethacin co crystal. Also, the method was capable of remodeling co crystal powder and showed significant advantages in terms of scale-up. In this study, we try to enhance the yield and purity of the crystal by combining the cooling method and anti-solvent method. Especially the cooling time point was important variable. The four kinds of cooling time points was observed the other crystal the purity and yield, crystallinity. These studies is eliciting indomethacin-saccharin co crystal formation process the optimum conditions. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were performed to characterize the off-line physicochemical properties of co-crystal powders. Near-infrared (NIR) spectroscopy was performed to Observe of the in-line process monitoring. More detailed data and findings shall be presented for a professional discussion. |
| 저자 | 천난희1, 이민정2, 왕인천2, 최광진1 |
| 소속 | 1순천향대, 2인제대 |
| 키워드 | cocrystal; indomethacin; saccharin; antisovlent; cooling |
| 원문파일 | 초록 보기 |
