| 학회 | 한국화학공학회 |
| 학술대회 | 2012년 가을 (10/24 ~ 10/26, 부산 BEXCO) |
| 권호 | 18권 2호, p.1643 |
| 발표분야 | 공정시스템 |
| 제목 | A mechanism study of anti-solvent co-crystallization by ATR-FTIR, XRD and DSC |
| 초록 | The pharmaceutical performance including the solubility, dissolution rate, and ultimately bioavailability of insoluble drugs (BCS classⅡ) such as indomethacin (IMC) and carbamazepine (CBZ) can be substantially improved by co-crystal approach. Until now, pharmaceutical co-crystals have been prepared by evaporation, grinding (neat or solvent-assisted), cooling, and supercritical operation. The preparation of IMC-SAC co-crystals by anti-solvent method was reported for the first time by our team. This approach has been well known for its primary advantages such as high production rate and process controllability. In this study, the mechanism of the co-crystal formation between IMC and SAC in the mixture of methanol and water was investigated. A change in saturation by adding water as anti-solvent would have caused a change in hydrogen bonding status between IMC and SAC. During the co-crystallization reaction, solutions were sampled periodically for at-line characterization using ATR-FTIR, XRD, and DSC. We observed consistent spectral shifts as co-crystallization made a progress. We will discuss the results in detail with thermodynamic analysis. |
| 저자 | 왕인천1, 최광진2 |
| 소속 | 1인제대, 2순천향대 |
| 키워드 | Co-crystallization; Anti-solvent; Indomethacin; Carbamazepine; evaporation; hydrogenbonding |
| 원문파일 | 초록 보기 |
