| 초록 |
Stress urinary incontience may be caused by urethral hypermobility or intrinsic sphincter deficiency. Whereas urethral hypermobility is usually treated by standard surgical procedures, such as colposuspension or sling trchniques, injectable materials are commonly used in patients with intrinsic sphincter deficiency. Injectable bulking agents, such as polytetrafluoroethylene particle, silicone particle, carbon particle, glutaraldehyde cross-linked collagen, and autologous fat, have been used for many years in the treatment of stress urinary incontinence (SUI). However, they showed some problems, such as particle migration and reabsorbtion (injection volume decrease). In this study, we developed polycarprolactone (PCL) particle-loaded poly(DL-lactic-co-glycolic acid) (PLGA) system as an injectable bulking agent to prevent particle migration and volume decrease in the applied site. PCL particles (diameter, 100~200 ㎛) were fabricated by a phase separtaion method and the particles were mixed with PLGA solution (10 wt% in tetraglycol) with different ratio. PCL is a nontoxic and tissue-compatible polymer having slower degradation rate than PLGA in the body. Tetraglycol is a nontoxic solvent for PLGA but nonsolvent for PCL. In the body, PCL-loaded PLGA solution becomes gel by the exchange of tetraglycol into water. PCL particle-loaded PLGA sol and gel were characterized.
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