| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Oral delivery of insulin using pH-responsive complexation gels prepared by using γ-irradiation |
| 초록 |
pH-Responsive poly(ethylene glycol) (PEG)-acrylic acid (AAc) gels were prepared by using γ-irradiation for controlled oral insulin delivery. The gel fraction was over 80% and the same amounts of PEG and AAc blended hydrogel had efficient insulin loading. The PEG-AAc gels exhibited unique pH-responsive properties in which interpolymer complexes were formed in acidic media and dissociated in neutral or basic environments. The insulin release from the gel was significantly retarded in acidic media while rapid release occurred under neutral/basic conditions. At the high pH solution, the gels swelled rapidly and over 70% of the insulin loaded was released over a period of 10 h. Within 2 h of administration of the insulin-containing gels, significant blood glucose reduction effects were showed in diabetic rats. The blood glucose reduction lasted for up to 10 h following administration. |
| 저자 |
권희정, 임윤묵, 김용수, 김우진, 노영창
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| 소속 |
한국원자력(연) |
| 키워드 |
: poly(ethylene glycol); acrylic acid; insulin; irradiation; drug delivery
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| E-Mail |
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