| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
학생우수논문발표(박사과정) |
| 제목 |
Anti-Senescence Ion-Delivering Nanocarrier for Recovering Therapeutic Properties of Long-Term-Cultured Human Adipose-Derived Stem Cells |
| 초록 |
The stemness and therapeutic functions of adipose-derived stem cells (ADSCs) decrease on long-term cell culture. To utilize long-term-cultured ADSCs (L-ADSCs), we designed a novel anti-senescence ion-delivering nanocarrier (AIN). We introduced to L-ADSCs AIN for delivering transition metal ions in an intracellular manner through endocytosis that can enhance angiogenic paracrine factor secretion. The low pH condition in the endosomes induced the release of transition metal ions in the L-ADSCs, which in turn caused a mild elevation in the levels of reactive oxygen species (ROS). The elevated mild ROS induced downregulation of senescence-related gene expression, whereas upregulation of stemness-related gene expression and angiogenic paracrine factor. |
| 저자 |
김영환, 방석호
|
| 소속 |
성균관대 |
| 키워드 |
Intracellular ion delivery; senescence; stem cell therapy
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| E-Mail |
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