| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Ion-Complexed Antibiotic for the Treatment of Osteomyelitis |
| 초록 |
Osteomyelitis is a bone infection by bacteria or fungus that causes severe bone damage. In recent years, antibiotic-loaded polymer matrix system has been frequently utilized to treat the osteomyelitis as a local delivery system. However, the insufficient release of antibiotics from the polymer matrix and secondary surgery to remove the polymer matrix still remained as critical limitations in clinical field. In this study, we developed ion-complexed antibiotic which can allow the sustained release of water-soluble antibiotic for sufficient period without any additional polymeric matrix, and thus can be an ideal system for the treatment of osteomyelitis. The drug release behavior, cytotoxicity, and anti-bacterial effect of the ion-complexed antibiotic were investigated. From the effective antibacterial effect caused by the continuously releasing doxycline, we can suggest that the ion-complexed doxycycline may be a promising therapeutic for the effective treatment of osteomyelitis. |
| 저자 |
남보라1, 오세행2, 김한울1, 이인수1, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
Osteomyelitis; Doxycycline; Ion-complexed antibiotic; Sustained release
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| E-Mail |
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