| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 기능성 고분자 |
| 제목 | Preparation of genistein nanocarriers using electrostatic interaction between the modified PLGA and genistein |
| 초록 | Genistein, an isoflavone phytonutrient obtained from soybeans1), nanocarriers were prepared using a biodegradable polymer2), poly(D,L lactide-co-glycolide) (PLGA) containing various contents of amine moieties, as a wall material. During the nanoprecipitation method, the influences of the surfactant types and concentrations on the stability of the nanocarriers were examined. In addition, the electrostatic behaviors (Scheme 1) between amine moieties in the PLGA and the hydroxyl groups on the genistein were investigated depending on the amine contents. The morphology (Figure 1), size, crystalline structure and zeta-potential of genistein/modified PLGA nanocarriers were measured utilizing TEM, DLS, DSC and Zeta-potential analyzer. Scheme 1. Bio-conjugation between the modified PLGA and hydroxyl group of genistein Figure 1. TEM image of genistein- nanocarriers Reference. 1) Alkel et al. Am J Clin Nutr 1998:68;1358 2) Labhasetwar et al. J Controlled Release 2003:92;173 |
| 저자 | 정재은1, 류지현1, 김진웅2, 서경도1 |
| 소속 | 1한양대, 2Harvard Univ. / 태평양기술(연) |
| 키워드 | genistein; nanocarrier |
