| 초록 |
Hydroxylated products of daidzein and genistein are a growing scientific interest for their health-related qualities. We have been interested in a microbial metabolite of isoflavone in highly aged Doenjang. Recently, we isolated three o-dihydroxyisoflavones (ODI), 6-hydroxydaidzein (6-OHD), 8-hydroxydaidzein (8-OHD) and 3`-hydroxydaidzein (3`-OHD), and evaluated some biological activity. ODIs show predominant effect on antioxidation activity and melanogenesis inhibition. And we studied the formation of modified isoflavones from daidzein and genistein by the genus Streptomyces. The great potential in applications such as the production of hydroxylated isoflavones and drug metabolites or bioremediation will be motivated for researchers to find new paradigm. |
